"A Gifted Man" centers on an ultra-competitive surgeon whose life is changed forever when his ex-wife dies and begins teaching him what life is all about from the here-after. Mamie Gummer guest-starred in the episode "In Case of Exposure": When Michael finds out a patient (John Benjamin Hickey) with a malignant brain tumor committed a horrible crime, he struggles with whether to save the man's life. Meanwhile, a female firefighter (Mamie Gummer) who appears to be disoriented is brought to Holt Neuro for evaluation.

Series Regulars: Patrick Wilson (Dr. Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita Perkins-Hall), Pablo Schreiber (Anton Little Creek), Rachelle Lefevre (Dr. Kate Sykora), Mike Doyle (Victor Lantz), Rhys Coiro (Dr. Zeke Barnes), Afton Williamson (Autumn), Armando Riesco (Tavo), Tijuana Ricks (Nurse Charisse), Sue Jean Kim (Nurse Colette)
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